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Product Name |
(+)-Negamycin |
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| Product Specifications | |
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| | catalogue no. | ME051 | |
| | chemical name | (+)-Negamycin | |
| | IUPAC name | (2-((3R,5R)-3,6-diamino-5-hydroxyhexanoyl)-1-methylhydrazinyl)-
acetic acid | |
| | molecular formula | C9H20N4O4 | |
| | molecular weight [g/mol] | 248.28 |
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| | CAS | 33404-78-3 | |
| | purity | 95%+ | |
| | category | Medchem Compounds | |
| | melting point | n.d. | |
| | boiling point | n.d. | |
| | appearance | solid | |
| | solubility | water | |
| | long term storage | -20oC | |
| | Spectra | 1-H NMR | |
| | NMR analytics | 600 MHz (CDCl3) | |
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| | Safety Information | |
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| | R-sentence | R: 36/37/38 | |
| | S-sentence | S: 26-24/25 | |
| | hazardous substance symbol | Xn | |
| | safety info | Caution, substance not fully tested. Potential health effects. | |
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| | References |
Hamada et al.: Hydrazide antibiotic isolated from strains related to Streptomyces purpeofuscus. J. Antibiot. 23, 170 (1970)
Ed T. Buurman et al.: Illicit Transport via Dipeptide Transporter Dpp is Irrelevant to the Efficacy of Negamycin in Mouse Thigh Models of Escherichia coli Infection. ACS Infect. Dis. 2015, 1, 222-230
A. Taguchi, K. Hamada, Y. Hayashi: Chemotherapeutics overcoming nonsense mutation-associated genetic diseases: medicinal chemistry of negamycin. J. Antibiot (Tokyo) 71, 205-214 (2018)
Y. Hayashi et al.: Negamycin Analogue with Readthrough-Promoting Activity as a Potential Drug Candidate for Duchenne Muscular Dystrophy. ACS Med. Chem. Lett. 2012, 3, 118-122
Thomas A. Steitz et al.: Negamycin inferes with decoding and translocation by simultaneous interaction with rRNA and tRNA. Molecular Cell 56, 1-10, 2014-11-20
Y. Hayashi et al.: Structure-activity relationship study of Leucyl-3-epi-deoxynegamycin for potent premature termination codon readthrough. ACS Med. Chem. Lett. 2017, 8, 1060-1065 | |
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| | Ordering Information |
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| Cat. No. |
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Product Name |
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Quantity |
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Price |
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| ME051.1 |
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(+)-Negamycin |
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1 mg |
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990,- € |
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| ME051.2 |
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(+)-Negamycin |
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2.5 mg |
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1980,- € |
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