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| thyroxine (T4) - BSA conjugate |
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Product Data |
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| | Product Name | thyroxine (T4) - BSA conjugate |
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| | Catalog No | CBS-8168 |
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| | Size | 1 mg |
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| | Price | 345,00 EUR |
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| | Category | drug BSA-conjugates |
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| | Description | thyroxine (T4), covalently linked to bovine serum albumin |
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| | Molecular Weight | app. 65 kDa |
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| | Presentation | liquid, 1 mg/ml solution in PBS, 0.05% sodium azide |
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| | Storage | 4°C |
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| | Conjugate/Tag/Label | BSA |
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| | Conjugation Ratio | app. 1:10 - 1:40 |
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| | Protein Source | bovine |
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| | Applications | e.g. allergy test, immunoassays etc. |
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| | Characteristics | The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production. |
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| | Purification | chromatography, dialysis |
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| | Concentration | 1 mg/ml |
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| | Working Dilution | test dependent |
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| | Considerations for Use | Please store at 4-8°C. Product is stable in the dark for 1 year 4-8°C in its stock solution. Working dilutions should always be prepared freshly. |
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