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HYDRA-O6-ethyl-2-deoxyguanosine immunoaffinity support
 
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  Product Name HYDRA-O6-ethyl-2-deoxyguanosine immunoaffinity support  
  Catalog No SQCM001  
  Size 1 ml  
  Price 845,00 EUR  
  Category Antibody affinity supports  
  Description HYDRA support for immunoaffinity purification of O6-ethyl-2-deoxyguanosine from biological samples  
  Feature Isolates a specific mutagenic DNA modification induced by several exogenous and endogenous carcinogens e.g. food, smoking, cancer therapeutics, environmental carcinogens, workplace carcinogens; Molecular epidemiology of carcinogen exposure; Pre- and intratherapeutic dosimetry of exposure to anticancer agents; Basic research of molecular mechanisms of carcinogenesis; Mutagenicity testing of substances  
  Appearance mAb immobilized to HYDRA immunochromatographic support  
  Presentation gel slurry in PBS, 0.05% sodium azide  
  Stabilizer none  
  Storage 4°C  
  Applications immunopurification of biological samples  
  Characteristics binding capacity: approx. 1-3 x e-9 Mol / ml polymethacrylate support  
  Host rat  
  Isotype rat IgG2b  
  Clonality monoclonal  
  Clone ER 6  
  Specificity O6-ethyl-2-deoxyguanosine  
  Cross Reactions see RIA specifity table (see graphics)  
  Affinity Constant 2.0 x 10 e10 (l/Mol)  
  Purification mAb purified by Protein G from cell culture supernatant  
  Expiry 3 years  
  Considerations for Use Please store the vial at 4-8 deg. C. The product is stable for 3 years at 4-8 deg. C.  
  Protocol see references  
  Keywords mutagenic DNA-modification; mAb, monoclonal antibody to modified DNA-base; mutagenicity testing, cacinogenesis, intratherapeutic dosimetry, molecular epidemiology; DNA-adduct; O-alkyl adduct detection in DNA, HYDRA immunoaffinity support  
 
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