Volume 4
New N-protected Aminoaldehydes
The Squarix Newsletter provides you with information about our innovative building blocks, reactive intermediates and screening compounds from our Discovery Chemicals portfolio.
In this issue we present new N-protected Aminoaldehydes especially designed for stereocontrolled organic synthesis.
Featured Products
AL001 AL025 AL028 AL032
AL001 AL025 AL028 AL032
AL034 AL043 AL044
AL034 AL043 AL044
These compounds are derived from natural and unnatural amino acids and are not commercially available from other manufacturers.
See our website for the full line of building blocks or download the Discovery Chemicals catalogue.
Please find also some selected references from the literature describing interesting applications of N-protected aminoaldehydes. The (E)-alkene dipeptide isostere of Trp-Val was synthesized using the key building block AL044 (Noda et al.). Evans et al. reported an efficient syntheses of L-Statine using L-Leucinal (AL040) as starting material :
1) M. Noda, T. Ibuka, H. Habashita, and N. Fuji, A Highly Stereoselective Synthesis of the Functionalized (E)-Alkene Dipeptide Isostere of Trp-Val via Organocyanocopper-Lewis Acid Mediated Reaction, Chem. Pharm. Bull 1997, 45, 1259-1264.
2) K.E. Rittle, C.F. Homnick, G.S. Ponticello and B.E. Evans, A Synthesis of Statine Utilizing an Oxidative Route to Chiral α-Amino Aldehydes1982, J. Org. Chem. 47, 3016-3018.
Discovery Chemicals
Custom Synthesis
Call us for a quote:
Squarix GmbH
Elbestraße 10
D-45768 Marl
fon: +49-2365-20400-0
fax: +49-2365-20400-60
web: www.squarix.de
e-mail: info@squarix.de
subscribe to Squarix newsletter
unsubscribe from Squarix newsletter
Download catalogue

Your personal data will never be disclosed to a third party. At any time you have access to your data for any change,
modification or cancellation. Do not hesitate to use this opportunity by sending a message to info@squarix.de