Volume 7
New building blocks for metathesis II
The Squarix Newsletter provides you with information about our innovative building blocks, reactive intermediates and screening compounds from our Discovery Chemicals portfolio.
In this issue we present new N-protected Olefin building blocks especially designed for Ring-Closing Metathesis (RCM) applications.
See below examples of possible useful transformation using our building blocks to synthesize e.g. macrocylic ring systems or nitrogen containing heterocycles via ring-closing metathesis.
  VA047 AS050      
  VA025 AS050      
These compounds are derived from natural and unnatural amino acids and are not commercially available from other manufacturers. Please find below a list of these new building blocks.
See our website for the full line of building blocks or download the Discovery Chemicals catalogue.
Featured Products
  VA047 VA048 VA049 VA050  
  VA051 VA052 VA001 VA002  
Please find also some selected references from the literature describing interesting applications of Ring-Closing Metathesis (RCM) reactions, the solid phase syntheses of cyclic peptoids (Khan et al.), the syntheses of nitrogen heterocycles (Kuhn et al.) and the synthesis of bicyclic lactams (Barret et al.).
educt 1 Reaction 1 product 1
  Cyclic Peptoids (Khan et al.)
educt 2 Reaction 2 product 2
  Nitrogen Heterocycles (Kuhn et al.)
educt 3 Reaction 3 product 3
  Bicyclic Beta-Lactams (Barret et al.)
1) S.N. Khan, A. Kim, R.H. Grubbs and Y-U. Kwon: Ring-Closing Metathesis Approaches for the Solid-Phase Synthesis of Cyclic Peptoids, Org. Lett. 2011, 13, 1582-1585.
2) K.M. Kuhn, T. M. Champagne, S.H. Hong, W-H. Wei, A. Nickel, C.W. Lee, S. C. Virgil, R. H. Grubbs and R.L. Pwederson: Low Catalyst Loadings in Olefin Metathesis: Synthesis of Nitrogen Heterocycles by Ring-Closing Metathesis, Org. Lett. 2010, 12, 984-987.
3) A.G.M. Barret, SPD. Baugh, V.C. Gibson, M.R. Giles, E.L. Marshall and P.A. Procopiou, Highly Functionalized Monocyclic and Bicyclic ß-Lactams via Alkene Metathesis, Chem. Commun. 1997, 155.
Discovery Chemicals
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