|
|
| |
|
|
|
|
| |
Product Name |
Rhodamine B-[(2,2'-bipyridine-4-yl)-aminocarbonyl]benzyl ester (RDA) |
|
| |
| |  |
|
| |
| Product Specifications | |
| |
| | catalogue no. | ME042 | |
| | chemical name | Rhodamine B-[(2,2'-bipyridine-4-yl)-aminocarbonyl]benzyl ester
(RDA) | |
| | IUPAC name | 9-[2-({[4-(2,2'-bipyridin-4-ylcarbamoyl)benzyl]oxy}-
carbonyl)phenyl]-6-(diethylamino)-N,N-diethyl-3H-xanthen-
3-iminium bromide | |
| | synonyms | RDA | |
| | molecular formula | C46H44BrN5O4 | |
| | molecular weight [g/mol] | 810.7767 (79.9045+730.8721) |
|
| | CAS | [ - ] | |
| | purity | 97%+ | |
| | category | Medchem Compounds | |
| | melting point | n.d. | |
| | boiling point | n.d. | |
| | appearance | purple solid | |
| | solubility | DMSO | |
| | long term storage | 4oC, stored dry and protected from light | |
| | Spectra | 1-H NMR | |
| | NMR analytics | 500 MHz (CDCl3) | |
| | characteristics | - Fe2+ specific fluorescent "sensor"
- Mitochondria specific
- Determination of the mitochondrial chelatable iron pool
- Assessment of: mitochondrial iron uptake
- Assessment of alterations of the mitochondrial chelatable iron pool under pathological conditions
- Assessment of the contribution of mitochondrial chelatable iron to physiological and pathological cellular processes
- Assessment of iron reduction | |
| |
| | Safety Information | |
| |
| | R-sentence | R: 36/37/38 | |
| | S-sentence | S: 26-24/25 | |
| | hazardous substance symbol | Xn | |
| | safety info | Caution, substance not fully tested. Potential health effects. | |
| |
| | References |
1. Selective determination of mitochondrial chelatable iron in viable cells with a new fluorescent sensor. F. Petrat et. al. Biochem. J. (2002) 362, 137-147
2. Cold-induced apoptosis of hepatocytes: mitochondrial permeability transition triggered by nonmitochondrial chelatable iron; U. Rauen et al. Free Radical Biology & Medicine, Vol. 35, No. 12, pp. 1664-1678, 2003
3. The chelatable iron pool in living cells: A methodically defined quantity. F. Petrat et. al. Biol. Chem., Vol. 383, pp. 489-502, 2002
4. Assessment of chelatable mitochondrial iron by using mitochondrion-selective fluorescent iron indicators with different iron-binding affinities. U. Rauen et al. ChemBioChem 2007, 8, 341-352
5. Oxidative inactivation of mitochondrial Aconitase results in iron and hydrogen peroxide-mediated neurotoxicity in rat primary mesencephalic cultures. David Cantu et. al. PlosOne, September 2009, Vol 4, Issue 9, p 1-9 | |
| |
| | Application Notes |
|
| | | The product is used as a selective, high quantum yield fluorescence marker for Fe2+ in biological samples, especially in mitochondria of viable cells. Measurements can be performed by fluorescence spectroscopy, fluorescence plate readers | |
| |
| | Ordering Information |
|
| |
| |
| Cat. No. |
| |
Product Name |
| |
Quantity |
| |
Price |
|
| |
| ME042.1 |
|
Rhodamine B-[(2,2'-bipyridine-4-yl)-aminocarbonyl]benzyl ester (RDA)-
|
|
1 mg |
|
325,- € |
|
| ME042.2 |
|
Rhodamine B-[(2,2'-bipyridine-4-yl)-aminocarbonyl]benzyl ester (RDA)-
|
|
5 mg |
|
975,- € |
|
| |
|
|
