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| mAb to O6-methyl-2-deoxyguanosine (EM 2-3) |
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Product Data |
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| | Product Name | mAb to O6-methyl-2-deoxyguanosine (EM 2-3) |
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| | Synonyms | EM 2-3 monoclonal antibody |
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| | Catalog No | SQM003.1 |
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| | Size | 100 µg |
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| | Price | 425,00 EUR |
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| | Category | Antibodies and Conjugates |
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| | Description | monoclonal antibody, specific for O6-methyl-2-deoxyguanosine |
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| | Background | DNA-lesion specific monoclonal antibody |
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| | Feature | Detects a specific mutagenic DNA modification induced by several exogenous and endogenous carcinogens e.g. food, smoking, cancer therapeutics, environmental carcinogens, workplace carcinogens; Molecular epidemiology of carcinogen exposure; Pre- and intratherapeutic dosimetry of exposure to anticancer agents; Basic research of molecular mechanisms of carcinogenesis; Mutagenicity testing of substances |
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| | Molecular Weight | 160 kDa |
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| | Presentation | lyophilized |
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| | Reconstitution | reconstitute with 1 ml of PBS, 0.05% sodium azide, 1% bovine serum albumine |
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| | Stabilizer | none |
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| | Storage | -20°C |
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| | Applications | competitive radioimmunoassay; ELISA; Immunoaffinity/Quantitative PCR; Immunocytochemistry: 0.05 - 0.2 µg/ml PBS containing 3% bovine serum albumin |
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| | Characteristics | specifically reacts with O6-methyl-2-deoxyguanosine in human, mouse, rat, hamster |
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| | Host | mouse |
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| | Isotype | IgG1 |
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| | Clonality | monoclonal |
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| | Clone | EM 2-3 |
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| | Immunogen | O6-methyl-2-deoxyguanosine-Thyroglubulin conjugate |
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| | Specificity | O6-methyl/ethyl/butyl-2-deoxyguanosine |
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| | Cross Reactions | in immunocytochemistry the antibody crossreacts efficiently with O6-ethyl-2-deoxyguanosine and O6-butyl-2-deosyguanosine |
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| | Affinity Constant | 4.4 x 10 e8 (l/Mol) |
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| | Purification | Protein G affinity purification from cell culture supernatant |
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| | Purity | >95% |
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| | Working Dilution | test dependent |
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| | Expiry | 1 year |
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| | Considerations for Use | Please store the vial at 4-8 deg. C. The product is stable for 1 year at 4-8 deg. C in its stock solution. Working dilutions should always be prepared freshly. For extended storage of the stock solution please add 50% glycerol and freeze the product. |
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