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T4-HRP conjugate
 
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  Product Name T4-HRP conjugate  
  Synonyms thyroxine T4 - horseradish peroxidase conjugate  
  Catalog No T4HRP.1  
  Size 1 mg  
  Price 325,00 EUR  
  Category drug HRP-conjugates  
  Description T4, covalently linked to horseradish peroxidase  
  Feature L-Thyroxine - enzyme conjugate with horseradish peroxidase; Reagent for T4 (L-Thyroxine) ELISA with commonly used anti T4-antibodies; High activity; Improved stability  
  Molecular Weight app. 44 kDa  
  Presentation lyophilized, 1 mg, essentially salt free  
  Reconstitution reconstitute with 1 ml PBS without azide  
  Stabilizer none  
  Storage -20°C  
  Conjugate/Tag/Label T4 (L-Thyroxine)  
  Conjugation Ratio 1:1  
  Protein Source horseradish peroxidase type VI-A  
  Applications T4 immunoassays development or other applications.  
  Use For research use only. Not intended for diagnostic use.  
  Purification preparative SEC chromatography  
  Concentration 1 mg/ml working concentration  
  Purity >99% (HPLC)  
  Activity 1500U/mg solid  
  Working Dilution working dilution: 1:5000 - 1:10000  
  Source horseradish  
  Additional Info The thyroid hormones, triiodothyronine (T3) and thyroxine (T4), are tyrosine-based hormones produced by the thyroid gland that are primarily responsible for regulation of metabolism. Iodine is necessary for the production of T3 and T4. A deficiency of iodine leads to decreased production of T3 and T4, enlarges the thyroid tissue and will cause the disease known as goitre. The major form of thyroid hormone in the blood is thyroxine (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly 20 to 1. T4 is converted to the active T3 (three to four times more potent than T4) within cells by deiodinases (5'-iodinase). These are further processed by decarboxylation and deiodination to produce iodothyronamine (T1a) and thyronamine (T0a). All three isoforms of the deiodinases are selenium-containing enzymes, thus dietary selenium is essential for T3 production.  
  Remarks conjugate with improved stability  
  Keywords thyroxine; T4; T3; thx; thyroxinal; Thyrax; Henning; tetraiodothyronine, triiodothyronine, diiodophenyl-L-alanine; DL-thyroxine, T4-HRP, T4-POD  
 
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